Drug Profile Drugs And Treatment And Prevention Of...

Warfarin Drug profile Generic name: Warfarin Trade names: Coumadin, Jantoven Drug class: vitamin K antagonist (Medicinenet.com, 2013) Formulations: Tablets: 1, 2, 2.5, 3, 4, 5, 6, 5, 7.5 and 10 mg. Powder for Injection: 5 mg/vial (Medicinenet.com, 2013) Indications: Warfarin is primarily used for treatment and prevention of venous thromboembolism, and to reduce risk of pulmonary embolism. Warfarin may also be used to prevent strokes in patients with atrial fibrillation or artificial heart valves. Contraindications: Warfarin is not recommended for use amongst pregnant women, unless they have a high risk of thromboembolism. Patients with recent CNS or traumatic surgery should also avoid use of warfarin, along with those that have bleeding or haemorrhagic tendencies. (Medicinenet.com, 2013) Adverse effects: Warfarin can commonly cause the following adverse effects: Nausea, loss of appetite, or stomach/abdominal pain, yellowing eyes/skin (Medicinenet, 2013). Warfarin is also potentially fatal as it can cause a major haemorrhage. Interactions: Drugs that commonly interact with warfarin include: capecitabine, imatinib, mifepristone, Aspirin, aspirin-like drugs (salicylates), and nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen,celecoxib). These drugs typically alter Warfarin’s anticoagulant effects, resulting in bleeding problems. (Medicinenet.com, 2013) Common antibiotics such as metronidazole reduce the metabolism of warfarin in the body,Show MoreRelatedSchool Of Pharmacy : Memo985 Words   |  4 Pagesprodrug that directly competes for the active site of thrombin.1 This direct inhibition inactivates both fibrin-bound and free form of thrombin. Because of its rapid onset and offset of action, there is no need for the initial parenteral anticoagulant treatment in patients with acute thrombosis.1 On the other hand, the enoxaparin indirectly inhibits factor Xa.2 It has a shorter duration of action (12h vs 24h) and a shorter half-life (4.5-7h vs 12-14h) in comparison to DE. The D E and the enoxaparin haveRead MoreAn Antagonist Of Vitamin And Its Effect On The Formation Of Thrombin2459 Words   |  10 PagesAll three of the drugs being studied do to some degree affect fundamental processes within a ‘coagulation cascade’. If one of the in vivo processes is altered within the cascade the cycle cannot complete with the formation of Thrombin. [Figure 2] Warfarin is an antagonist of vitamin K used to treat reoccurrence of DVT and pulmonary embolisms. ‘Stenflo Nelsestuen, 1974’ showed prothrombin ‘the precursor to thrombin’ to contain a number of glutamate residues relatingRead MoreThe Prevalence Of Strokes Among Women2725 Words   |  11 Pagescharacteristics that manifest in different ways in relation to males. 7 Specific risk factors unique to young women that cultivate this condition include atrial fibrillation, migraines, the use of birth control pills, and pregnancy. 2,3,5,7 Although stroke treatment focuses on dissolution and extraction of the clot, preventive medicine is the most effective. 7 In order to prevent strokes in young women, accurate etiological determination of the stroke must be recognized. The expansion of diagnostic classificationRead MoreHeart Failure : A Clinical Syndrome Characterized By Structural Or Functional Impairment Of Ventricular8006 Words   |  33 Pagesadvanced diseas e - Gastrointestinaldiscomfort - Anorexia - Early satiety - Confusion, especially in the elderly - Depression - Palpitations - Syncope †¢ Physical examination 4 5 13 o Most specific signs of heart failure include: - Elevated jugular venous pressure - Positive hepatojugular reflex - Laterally displaced apical impulse on auscultation - Presence of third heart sound on auscultation o Less specific signs of heart failure may include: - Wheezing on auscultation - Rales on auscultation -Read MoreCase Study Essay33967 Words   |  136 Pagesdischarged from the hospital for exacerbated HF. Comprehensive patient education starting at admission is considered a standard of care and is mandated by The Joint Commission when providing care to hospitalized patients. The goal of the discharge treatment plan is to facilitate successful patient selfmanagement, minimize symptoms, and prevent readmission. CASE STUDY PROGRESS During the admission interview, the nurse makes a list of the medications M.G. took at home. ââ€"   Chart View Nursing Assessment:Read MoreDental Question Bank33485 Words   |  134 Pagespulp exposure. B. Removal of caries has exposed the pulp C. When carious lesion has just penetrated DEJ 21. Following trauma to tooth, the next day there was no response to pulp tests you should A. Review again later 4 B. C. Start endodontic treatment Extraction of tooth 22. What is the main purpose of performing pulp test on a recently traumatised tooth A. B. Obtain baseline response Obtain accurate indication about pulp vitality 23. What is the main function of EDTA in endodontics A. Decalcification